Dr. Ruby Huang
Dr. Ruby Yun-Ju Huang graduated from National Taiwan University (NTU) with the MD degree in 1999 and completed her Obstetrics & Gynecology (ObGyn) residency training in National Taiwan University Hospital (NTUH) and obtained the Taiwan ObGyn Specialist Board in 2003. Subsequently, she received sub-specialization training as a Clinical Fellow in the Department of Oncology in NTUH for Surgical Oncology discipline from 2003 to 2006.
During that time, she discovered her strong interest in research and started a PhD study in the Graduate Institute of Anatomy and Cell Biology of NTU in 2004. She decided to work as a clinician-scientist (CS) with a focus in gynaecologic oncology and specifically in ovarian cancer. In 2006, she was awarded the FIGO / BSP Postdoctoral Research Fellowship and joined Prof. Nelly Auersperg’s lab in University of British Columbia (UBC) to study epithelial-mesenchymal transition (EMT) of human ovarian surface epithelium (OSE). She obtained her PhD degree in 2008 from NTU and joined Prof. Jean Paul Thiery’s team as a post-doc in Institute of Molecular and Cell Biology (IMCB) of A*STAR. During this 2-year stint, she focused on the genomic alterations and the mechanism of EMT in ovarian cancer. Subsequently, she joined Department of Obstetrics & Gynaecology (O&G) in NUH in Sep 2009. Working as a CS with protected time, she has been carrying the mission and tasks to establish the translational research program for the Division of Gynae Oncology ever since. She is also affiliated with Cancer Science Institute (CSI) of Singapore in National University of Singapore (NUS).
She established the integrative genomic platforms and pre-clinical models for understanding the regulation of EMT in ovarian cancer and a novel functions of several tyrosine kinase inhibitors. She also co-discovered the presence of five molecular subtypes in epithelial ovarian cancer that exhibit different epithelial and mesenchymal characteristics having different chemosensitivity to anti-microtubule agent. Moving towards a more senior role in research, she has led the research in defining the EMT scoring and understanding the underlying biology of molecular subtypes of EOC. She is now an Adjunct Assistant Professor in Department of Anatomy of NUS, Principal Associate in CSI Singapore, and Senior Resident Physician of Department of O&G in NUH. She is happily married with one lovely son.